Subramanian Subbaya, Madgula Vamsi M, George Ranjan, Kumar Satish, Pandit Madhusudhan W, Singh Lalji
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India.
Comp Funct Genomics. 2003;4(3):342-5. doi: 10.1002/cfg.289.
Simple sequence repeats are predominantly found in most organisms. They play a major role in studies of genetic diversity, and are useful as diagnostic markers for many diseases. The simple sequence repeats database (SSRD) for the human genome was created for easy access to such repeats, for analysis, and to be used to understand their biological significance. The data includes the abundance and distribution of SSRs in the coding and non-coding regions of the genome, as well as their association with the UTRs of genes. The exact locations of repeats with respect to genomic regions (such as UTRs, exons, introns or intergenic regions) and their association with STS markers are also highlighted. The resource will facilitate repeat sequence analysis in the human genome and the understanding of the functional and evolutionary significance of simple sequence repeats. SSRD is available through two websites, http://www.ccmb.res.in/ssr and http://www.ingenovis.com/ssr.
简单序列重复在大多数生物体中普遍存在。它们在遗传多样性研究中发挥着重要作用,并且作为许多疾病的诊断标记很有用。人类基因组的简单序列重复数据库(SSRD)是为了便于获取此类重复序列、进行分析以及用于理解其生物学意义而创建的。数据包括简单序列重复在基因组编码区和非编码区的丰度和分布,以及它们与基因非翻译区的关联。还突出显示了重复序列相对于基因组区域(如非翻译区、外显子、内含子或基因间区域)的确切位置及其与序列标签位点标记的关联。该资源将促进人类基因组中的重复序列分析以及对简单序列重复的功能和进化意义的理解。可通过两个网站获取SSRD,即http://www.ccmb.res.in/ssr和http://www.ingenovis.com/ssr。