Coates Laura C, Helliwell Philip S
Clin Rheumatol. 2008 Oct;27(10):1211-6. doi: 10.1007/s10067-008-0947-4. Epub 2008 Jul 16.
For over 30 years, investigators have used the simple but non-validated classification criteria suggested by Moll and Wright. Several authors have suggested modifications to these but most remain unvalidated or require human leukocyte antigen analysis. Now, a worldwide initiative has developed new criteria which include both clinical and radiological features. These will require further study before they are fully adopted but their improved performance should result in less variation between study cohorts. The recurring question of disease heterogeneity continues to occupy researchers in this field. Despite recent pleas to abandon the original five sub-groups, a case can be made for retaining at least the two sub-groups of peripheral and axial disease and, possibly, splitting the peripheral disease into oligo- and poly-arthritis.
30多年来，研究人员一直使用莫尔（Moll）和赖特（Wright）提出的简单但未经验证的分类标准。几位作者建议对这些标准进行修改，但大多数修改仍未经验证或需要进行人类白细胞抗原分析。现在，一项全球倡议制定了新的标准，其中包括临床和放射学特征。在这些标准被全面采用之前，还需要进一步研究，但它们改进后的性能应会减少研究队列之间的差异。疾病异质性这个反复出现的问题继续困扰着该领域的研究人员。尽管最近有人呼吁放弃原来的五个亚组，但仍有理由至少保留外周型和中轴型疾病这两个亚组，并且可能将外周型疾病分为寡关节炎型和多关节炎型。
