Büssing Arndt, Tröger Wilfried, Stumpf Cristina, Schietzel Michael
University Witten/Herdecke, Herdecke, Germany.
Anticancer Res. 2008 May-Jun;28(3B):1893-7.
In a previous study a decline of T-lymphocyte function was observed within a 6-month period of Viscum album extract (VA-E) application which did not occur in those patients with dose adaptation in response to strong local reactions (LR) or in those with moderate LR. To further investigate the immunological prerequisites of these differences in the VA-E susceptibilities, an analysis was carried out of the pre-existing differences in the tumor patients' lymphocyte subsets, and of whether the LR pattern (none, moderate, strong) might be associated with distinct aspects of the patients' quality of life.
Seventy-one cancer patients were subcutaneously treated with VA-E (Iscador) at increasing concentrations and their lymphocyte subsets measured by flowcytometry during a 6 month observation period; quality of life was assessed with the HLQ questionnaire.
The occurrence of stronger LR was associated with a primarily higher level of T-cells and their CD4+ T-helper/inducer subset, and CD25+ respectively HLA-DR+ (activated) T-cells. Moreover, counts or proportions of T-cells, CD4+ T-helper/inducer cells and CD8+ CD28+ cytotoxic cells were lower, while the relative proportions of CD8+ CD28- suppressor cells, B- and NK-cells were the highest in the group with moderate LR. In particular, this latter group had a significantly higher quality of life.
Our results indicate that the induction of moderate LR in response to VA-E application was associated with better T cell function and quality of life. Extracts from Viscum album (VA-E) are widely used as a
在之前的一项研究中，观察到在应用欧洲白蜡树提取物（VA-E）的6个月期间，T淋巴细胞功能出现下降，但在那些因强烈局部反应（LR）而进行剂量调整的患者或中度LR患者中未出现这种情况。为了进一步研究这些VA-E易感性差异的免疫前提条件，对肿瘤患者淋巴细胞亚群的预先存在的差异以及LR模式（无、中度、强烈）是否可能与患者生活质量的不同方面相关联进行了分析。
71名癌症患者接受皮下注射不同浓度的VA-E（Iscador）治疗，并在6个月的观察期内通过流式细胞术测量其淋巴细胞亚群；使用HLQ问卷评估生活质量。
较强LR的出现主要与较高水平的T细胞及其CD4 + T辅助/诱导亚群、CD25 +以及HLA-DR +（活化）T细胞相关。此外，T细胞、CD4 + T辅助/诱导细胞和CD8 + CD28 +细胞毒性细胞的计数或比例较低，而在中度LR组中，CD8 + CD28 -抑制细胞、B细胞和NK细胞的相对比例最高。特别是，后一组的生活质量明显更高。
我们的结果表明，对VA-E应用产生中度LR与更好的T细胞功能和生活质量相关。欧洲白蜡树提取物（VA-E）被广泛用作一种
