Barta A, Kalyna M, Lorković Z J
Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria.
Curr Top Microbiol Immunol. 2008;326:83-102. doi: 10.1007/978-3-540-76776-3_5.
SR proteins are a family of splicing factors important for splice site recognition and spliceosome assembly. Their ability to bind to RNA and to interact with proteins as well identifies them as important players in splice site choice and alternative splicing. Plants possess twice as many SR proteins as animals, and some of the subfamilies are plant specific. Arabidopsis SR proteins are involved in different aspects of plant growth and development as well as in responses to environmental cues. The plant-specific subfamilies have been shown to be regulated by alternative splicing events, which are highly conserved in evolution. The tight regulation of splicing factors by alternative splicing might allow coordinated responses of their target genes.
SR蛋白是一类剪接因子，对剪接位点识别和剪接体组装至关重要。它们与RNA结合以及与蛋白质相互作用的能力也使其成为剪接位点选择和可变剪接中的重要参与者。植物拥有的SR蛋白数量是动物的两倍，并且一些亚家族是植物特有的。拟南芥SR蛋白参与植物生长发育的不同方面以及对环境信号的响应。已表明植物特有的亚家族受可变剪接事件调控，这些事件在进化中高度保守。通过可变剪接对剪接因子进行严格调控可能使其靶基因产生协调反应。
