Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, 60438 Frankfurt a.M., Germany.
School of Biological Sciences, Monash University, Clayton, VIC 3800, Australia.
Biomolecules. 2020 Sep 11;10(9):1310. doi: 10.3390/biom10091310.
Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.
信号转导和基因表达的调控是每个细胞的基本过程。RNA 结合蛋白（RBPs）在响应内外刺激的转录后基因表达调控中发挥关键作用。然而，信号通路如何调节 RBPs 与 mRNAs 的组装在很大程度上仍然未知。在这里，我们总结了一些观察结果，表明信使核糖核蛋白颗粒（mRNP）的形成和组成在空间和时间上通过特定的信号级联和由此产生的翻译后修饰进行动态重塑。将信号事件与基因表达整合起来是细胞快速适应环境变化和应激的关键。只有综合分析信号转导途径以及它们引起的转录后基因表达变化的方法，才能揭示协调这些重要细胞过程的机制。
