Fotuhi Majid, Zandi Peter P, Hayden Kathleen M, Khachaturian Ara S, Szekely Christine A, Wengreen Heidi, Munger Ronald G, Norton Maria C, Tschanz Joann T, Lyketsos Constantine G, Breitner John C S, Welsh-Bohmer Kathleen
Department of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain & Spine Institute, Baltimore, MD, USA.
Alzheimers Dement. 2008 May;4(3):223-7. doi: 10.1016/j.jalz.2008.01.004. Epub 2008 Apr 21.
Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE epsilon4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE epsilon4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.
研究表明，服用抗氧化维生素或非甾体抗炎药（NSAIDs）的老年人认知能力下降较少，患阿尔茨海默病的风险较低。尚未对两者联合使用带来额外益处的可能性进行研究。因此，我们分析了来自卡什县研究的3376名老年参与者的数据，这些参与者在8年期间接受了多达三次的改良简易精神状态检查。在基线时同时使用维生素E和C补充剂及NSAIDs的参与者，每3年平均比未使用者少下降0.96分（P < 0.05）。这种明显的效果完全归因于携带APOE ε4等位基因的参与者，其使用者每3年比未使用者少下降2.25分（P < 0.05）。这些结果表明，在携带APOE ε4等位基因的老年人中，联合使用抗氧化补充剂和NSAIDs与随时间推移认知能力下降较少之间存在关联。
