School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Eur J Nutr. 2014 Aug;53(5):1255-62. doi: 10.1007/s00394-013-0628-1. Epub 2013 Dec 11.
This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran.
About 256 elderly with mild cognitive impairment, aged 60-75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year.
Demographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined.
Antioxidant supplementation reduced malondialdehyde level (P < 0.001) and raised total antioxidant capacity (P < 0.001) and glutathione (P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged (P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively).
Despite significant improvement in most of the oxidative stress biomarkers, antioxidants' supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected.
本研究旨在探讨伊朗老年人补充维生素 E 和 C 对认知表现的影响。
约 256 名年龄在 60-75 岁之间、有轻度认知障碍的老年人每天接受 300 毫克维生素 E 和 400 毫克维生素 C 或安慰剂治疗，为期 1 年。
检测了人口统计学特征、人体测量学变量、食物摄入量、采用简易精神状态检查（MMSE）评估的认知功能以及一些氧化应激生物标志物。
抗氧化补充剂降低了丙二醛水平（P < 0.001），提高了总抗氧化能力（P < 0.001）和谷胱甘肽水平（P < 0.01）。血清 8-羟基脱氧鸟苷酸没有变化（P < 0.4）。在调整了协变量的影响后，经过 6 个月（25.88 ± 0.17）和 12 个月抗氧化补充剂治疗后的 MMSE 评分（26.8 ± 0.17）与对照组（25.86 ± 0.18 和 26.59 ± 0.18）没有差异。
尽管大多数氧化应激生物标志物显著改善，但抗氧化剂补充剂并未观察到对认知表现有增强作用。可能怀疑存在大量动力学和/或动态因素。
