Gholami Zeinab, Maracy Mohammad Reza, Paknahad Zamzam
Department of Clinical Nutrition, School of Nutrition and Food Science, Students' Research Committee Isfahan University of Medical Sciences Isfahan Iran.
Department of Epidemiology and Biostatistics, School of Health Isfahan University of Medical Sciences Isfahan Iran.
Health Sci Rep. 2024 Aug 12;7(8):e2262. doi: 10.1002/hsr2.2262. eCollection 2024 Aug.
Metabolic syndrome (MetS) is the main general and clinical health challenge worldwide. Based on the National Cholesterol Education Program, if the person has three or more indices containing: elevated fasting blood sugar, high levels of triglycerides, hypertension, low levels of high-density lipoprotein cholesterol, and central obesity, he suffers MetS. The Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay diet is a novel diet that with the specific aim of safeguarding cognitive function. Propolis is a resinous substance produced by bees from the combination of buds and secretions of plants with saliva and bee enzymes. After propolis supplementation, a significant reduction in fasting plasma glucose levels and lipid profiles has been observed. Considering the importance of chronic diseases like MetS on health, the role of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and propolis supplement that will improve blood sugar, blood lipid, anthropometric indicators, blood pressure, and cognitive function, and limited contradictory studies, we decided to conduct this study. This study, which is a randomized controlled clinical trial study, will be conducted on adults with MetS who will visit Hazrat Ali Health Center in Isfahan. Participants must provide informed consent before engaging in the study. Demographic data such as age, gender, and medical history will be recorded. Then, anthropometric indices, MetS indices, and cognitive function will be measured in all subjects. The study participants will be divided into three groups and will be controlled for 12 weeks. We will have a MIND diet + placebo group, a MIND diet + propolis supplement group, and a control group that will receive a microcrystalline cellulose placebo and usual dietary advice. At the end of the intervention, all indices will be assessed again. The data obtained in the study will be analyzed at descriptive and analytical levels by the statistical software SPSS. The present study's protocol was approved by the Iranian Registry of Clinical Trials (www.irct.ir) on 3/28/2023 and a registration reference is IRCT20230105057054N1.
代谢综合征（MetS）是全球主要的总体和临床健康挑战。根据美国国家胆固醇教育计划，如果一个人有三个或更多指标，包括：空腹血糖升高、甘油三酯水平高、高血压、高密度脂蛋白胆固醇水平低和中心性肥胖，那么他就患有代谢综合征。地中海式饮食预防高血压（DASH）延缓神经退行性变饮食是一种新型饮食，其特定目标是保护认知功能。蜂胶是蜜蜂将植物的芽和分泌物与唾液及蜜蜂酶混合后产生的树脂状物质。补充蜂胶后，空腹血糖水平和血脂谱有显著降低。考虑到像代谢综合征这样的慢性病对健康的重要性，以及地中海式延缓神经退行性变（MIND）饮食和蜂胶补充剂在改善血糖、血脂、人体测量指标、血压和认知功能方面的作用，且相关矛盾研究有限，我们决定开展这项研究。本研究是一项随机对照临床试验研究，将针对患有代谢综合征的成年人进行，这些成年人将前往伊斯法罕的哈扎特·阿里健康中心就诊。参与者在参与研究前必须提供知情同意书。将记录年龄、性别和病史等人口统计学数据。然后，将对所有受试者测量人体测量指标、代谢综合征指标和认知功能。研究参与者将分为三组，并进行12周的对照。我们将有一个MIND饮食+安慰剂组、一个MIND饮食+蜂胶补充剂组和一个对照组，对照组将接受微晶纤维素安慰剂和常规饮食建议。在干预结束时，将再次评估所有指标。研究中获得的数据将通过统计软件SPSS在描述性和分析性层面进行分析。本研究方案于2023年3月28日获得伊朗临床试验注册中心（www.irct.ir）批准，注册编号为IRCT20230105057054N1。
