Okamura Mikio, Kamiizumi You, Kawamura Norio, Yokoyama Ryoji, Itoh Koji, Abe Kenji, Nakajima Yasuaki
Dept. of Surgery, Iwamizawa Municipal General Hospital.
Gan To Kagaku Ryoho. 2008 Jul;35(7):1205-7.
A 78-year-old male with sigmoid colon cancer underwent sigmoidectomy. The lesion was se, p1(+), n1, and Stage IV. Oral UFT therapy was performed, but was replaced with oral S-1 therapy 1 year and 6 months after surgery. Three months later, lung metastases 2.0 x 1.5 cm and 0.6 x 0.6 cm were found by chest CT in right S10a and S5b, respectively. Since the patient did not wish surgery, the treatment was changed to oral UFT/Leucovorin(LV)therapy(UFT 300 mg/ LV 75 mg, 4-week administration and 1-week no-administration periods). After 2 courses, chest CT showed disappearance of both lung metastases, indicating complete remission. Oral UFT/LV therapy is convenient because of the oral route. Adverse reactions are few, and the therapeutic effect has been reported to be comparable to that of intravenous 5-FU/LV therapy. Also, in this patient, no adverse reaction was noted, and complete remission was maintained until the patient died of another disease 31 months after the beginning of oral UFT/LV therapy.
一名78岁的乙状结肠癌男性患者接受了乙状结肠切除术。病变为se，p1(+)，n1，IV期。进行了口服优福定治疗，但在术后1年6个月改为口服S-1治疗。三个月后，胸部CT分别在右肺S10a和S5b发现了2.0×1.5 cm和0.6×0.6 cm的肺转移灶。由于患者不希望进行手术，治疗改为口服优福定/亚叶酸钙（LV）治疗（优福定300 mg/亚叶酸钙75 mg，给药4周，停药1周）。两个疗程后，胸部CT显示两个肺转移灶均消失，达到完全缓解。口服优福定/LV治疗因采用口服途径而方便。不良反应少，据报道其治疗效果与静脉注射5-氟尿嘧啶/LV治疗相当。此外，该患者未出现不良反应，在口服优福定/LV治疗开始31个月后因另一种疾病死亡前一直维持完全缓解状态。
