Cliquet F, Guiot A L, Schumacher C, Maki J, Cael N, Barrat J
WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, AFSSA, Malzeville, France.
Dev Biol (Basel). 2008;131:257-64.
Oral vaccination programmes conducted in rabies infected countries from Eastern Europe and Eurasia should not be restricted to foxes but should target other major rabies vectors such as dogs and raccoon dogs as well. The objective of this experimental trial was to assess the protection induced by the vaccine by challenging these different species, which had been previously vaccinated intramuscularly with the square V-RG baits (produced in the US). Different parameters were evaluated such as attractiveness of the baits and induction of neutralising antibodies as an indicator for immunogenicity and protection after rabies challenge. The acceptability of the square bait was satisfactory in dogs, foxes and raccoon dogs, confirming previous laboratory and field studies conducted with the rectangular baits. Only one vaccinated dog out of nine seroconverted after vaccination and among them one dog died of rabies. Eight of ten vaccinated foxes seroconverted after vaccination and survived the rabies challenge. All vaccinated raccoon dogs seroconverted after challenge and all survived the challenge. These trials demonstrated that the square presentation of the V-RG vaccine was attractive, immunogenic and efficacious.
在东欧和欧亚大陆受狂犬病感染的国家开展的口服疫苗接种计划不应局限于狐狸，还应以狗和貉等其他主要狂犬病传播媒介为目标。这项实验性试验的目的是通过对这些先前已通过肌肉注射美国生产的方形V-RG诱饵进行疫苗接种的不同物种进行攻毒，来评估疫苗诱导的保护作用。评估了不同参数，如诱饵的吸引力以及中和抗体的诱导情况，以此作为免疫原性指标以及狂犬病攻毒后保护作用的指标。方形诱饵在狗、狐狸和貉中的可接受性令人满意，这证实了先前使用长方形诱饵进行的实验室和现场研究结果。接种疫苗后，9只接种疫苗的狗中只有1只出现血清转化，其中1只狗死于狂犬病。10只接种疫苗的狐狸中有8只在接种疫苗后出现血清转化，并在狂犬病攻毒中存活下来。所有接种疫苗的貉在攻毒后都出现血清转化，并且全部在攻毒中存活。这些试验表明，V-RG疫苗的方形剂型具有吸引力，并具有免疫原性和有效性。
