Silies Marion, Edenfeld Gundula, Engelen Daniel, Stork Tobias, Klämbt Christian
Institut für Neurobiologie, Universität Münster, D-48149 Münster, Germany.
Neuron Glia Biol. 2007 Feb;3(1):35-43. doi: 10.1017/S1740925X07000622.
In complex organisms the nervous system comprises two cell types: neurons and glial cells. Their correct interplay is of crucial importance during both the development of the nervous system and for later function of the nervous system. In recent years tools have been developed for Drosophila that enable genetic approaches to understanding glial development and differentiation. Focusing on peripheral glial cells we first summarize wild-type development, then introduce some of the relevant genes that have been identified. Despite obvious differences between Drosophila and mammalian glial cells, the molecular machinery that controls terminal differentiation appears well conserved.
在复杂生物体中，神经系统由两种细胞类型组成：神经元和神经胶质细胞。它们之间正确的相互作用在神经系统发育过程中以及神经系统的后期功能中都至关重要。近年来，针对果蝇开发了一些工具，这些工具能够采用遗传学方法来理解神经胶质细胞的发育和分化。我们首先聚焦于外周神经胶质细胞，总结其野生型发育过程，然后介绍一些已鉴定出的相关基因。尽管果蝇和哺乳动物的神经胶质细胞存在明显差异，但控制终末分化的分子机制似乎高度保守。
