Shimizu Yukihiro
World J Gastroenterol. 2008 Jul 14;14(26):4111-9. doi: 10.3748/wjg.14.4111.
Potential causes of abnormal liver function tests include viral hepatitis, alcohol intake, nonalcoholic fatty liver disease, autoimmune liver diseases, hereditary diseases, hepatobiliary malignancies or infection, gallstones and drug-induced liver injury. Moreover, the liver may be involved in systemic diseases that mainly affect other organs. Therefore, in patients without etiology of liver injury by screening serology and diagnostic imaging, but who have systemic diseases, the abnormal liver function test results might be caused by the systemic disease. In most of these patients, the systemic disease should be treated primarily. However, some patients with systemic disease and severe liver injury or fulminant hepatic failure require intensive treatments of the liver.
肝功能检查异常的潜在原因包括病毒性肝炎、酒精摄入、非酒精性脂肪性肝病、自身免疫性肝病、遗传性疾病、肝胆恶性肿瘤或感染、胆结石以及药物性肝损伤。此外，肝脏可能会参与主要影响其他器官的全身性疾病。因此，在通过血清学筛查和诊断性影像学检查未发现肝损伤病因，但患有全身性疾病的患者中，肝功能检查结果异常可能是由全身性疾病引起的。在大多数这类患者中，应首先治疗全身性疾病。然而，一些患有全身性疾病且肝损伤严重或发生暴发性肝衰竭的患者需要对肝脏进行强化治疗。
