Olyntho-Tokunaga H H V, Pinto M L, Souccar C, Schoorlemmer G H M, Lapa R C R S
Department of Morphology, Universidade Federal de São Paulo, SP, Brazil.
Anat Histol Embryol. 2008 Dec;37(6):438-41. doi: 10.1111/j.1439-0264.2008.00877.x. Epub 2008 Jul 15.
To analyse the effect of ageing on the projection of the anterior interposed nucleus to the red nucleus, we injected the retrograde tracer fluorogold in the red nucleus of 3-, 6- and 12-month-old mice. The number of labelled neurones in the anterior interposed nucleus fell by 9% between 3 and 6 months and by another 9% between 6 and 12 months (all P < 0.001). This suggests that loss of neurones from the cerebellar nuclei starts well before old age.
