Cerman A A, Bozkurt S, Sav A, Tulunay A, Elbaşi M O, Ergun T
Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.
Br J Dermatol. 2008 Sep;159(4):820-6. doi: 10.1111/j.1365-2133.2008.08742.x. Epub 2008 Jul 15.
Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.
To investigate the possible role of leptin in psoriasis pathogenesis.
Forty-three patients with psoriasis, 10 diseased and 10 healthy controls with normal body mass index were included. Serum fasting leptin levels of the study group were examined by enzyme-linked immunosorbent assay. Tissue leptin and leptin receptor expression of both patients and controls were investigated by immunohistochemistry.
Serum leptin levels, tissue leptin and leptin receptor expression were significantly higher in patients with severe psoriasis than patients with mild-moderate psoriasis and controls (P < 0.05). Serum leptin levels showed a positive correlation with Psoriasis Area and Severity Index and involved body surface area in patients with psoriasis. In addition, serum leptin levels, tissue leptin and leptin receptor expression showed a positive correlation with disease duration in patients with psoriasis (P < 0.01, r = 0.979; P < 0.01, r = 0.691; P < 0.01, r = 0.428, respectively).
We assume that leptin might serve as a marker of severity in psoriasis and also may be a pathogenetic cofactor contributing to chronicity of the disease. Consequently, its role in obesity and cardiovascular disease in patients with psoriasis deserves to be studied. In addition, drugs targeting the proinflammatory effects of leptin may be a new adjuvant therapeutic approach in psoriasis.
近期研究支持银屑病与肥胖及心血管疾病之间的关联。瘦素是一种主要由脂肪组织分泌的肽类激素，参与能量摄入与消耗的调节。近来，已证实其具有多种免疫效应，包括诱导促炎细胞因子的产生。
探讨瘦素在银屑病发病机制中的可能作用。
纳入43例银屑病患者、10例体重指数正常的患病对照者及10例健康对照者。通过酶联免疫吸附测定法检测研究组患者的血清空腹瘦素水平。采用免疫组织化学法研究患者及对照者的组织瘦素和瘦素受体表达情况。
重度银屑病患者的血清瘦素水平、组织瘦素及瘦素受体表达显著高于轻度至中度银屑病患者及对照者（P < 0.05）。银屑病患者的血清瘦素水平与银屑病面积和严重程度指数及受累体表面积呈正相关。此外，银屑病患者的血清瘦素水平、组织瘦素及瘦素受体表达与病程呈正相关（分别为P < 0.01，r = 0.979；P < 0.01，r = 0.691；P < 0.01，r = 0.428）。
我们推测瘦素可能是银屑病严重程度的一个标志物，也可能是导致该疾病慢性化的致病辅助因子。因此，其在银屑病患者肥胖及心血管疾病中的作用值得研究。此外，针对瘦素促炎作用的药物可能是银屑病一种新的辅助治疗方法。
