Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA.
Department of Rheumatology, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, USA.
Semin Arthritis Rheum. 2023 Apr;59:152165. doi: 10.1016/j.semarthrit.2023.152165. Epub 2023 Jan 18.
Psoriatic disease (PD) and non-alcoholic fatty liver disease (NAFLD) potentially share disease pathways given the numerous inflammatory pathways involved in both diseases and a higher prevalence of NAFLD in PD patients. Metabolic syndrome and obesity are a key link between the two diseases, but even when controlling for this, associations between both diseases are still seen. Therapeutics that impact metabolic or inflammatory pathways may be impactful in both PD and NAFLD. In this review, we describe common inflammatory pathways contributing to both PD and NAFLD and critically review the potential impact of treatments for and on both diseases.
银屑病(PD)和非酒精性脂肪性肝病(NAFLD)可能具有共同的疾病途径,因为这两种疾病都涉及许多炎症途径,且 PD 患者中 NAFLD 的患病率更高。代谢综合征和肥胖是这两种疾病之间的关键联系,但即使在控制了这一因素后,这两种疾病之间仍存在关联。影响代谢或炎症途径的治疗方法可能对 PD 和 NAFLD 都有影响。在这篇综述中,我们描述了导致 PD 和 NAFLD 的共同炎症途径,并批判性地回顾了治疗 PD 和 NAFLD 的潜在影响。