Park Mushik, Kim Sungpo, Kim In Seop, Son Daegu
Department of Plastic and Reconstructive Surgery, Dongsan Medical Center, Keimyung University, Daegu, South Korea.
Wound Repair Regen. 2008 Jul-Aug;16(4):520-8. doi: 10.1111/j.1524-475X.2008.00399.x.
The effects of amniotic membranes (AMs), either fresh human and bovine AMs or acellular bovine AMs, on wound healing were compared among the burn wounds of porcine skin. Six pigs were chosen for the study, and we created deep second-degree contact burns on them with a digitally controlled aluminum thermal block. Then we applied the dressings to some of the wounds using fresh human and bovine AMs, acellular bovine AMs, polyurethane foam, or no dressing. We evaluated the pigs for (1) the rate of epithelialization, (2) histological grading, and (3) infections. We found that the AM groups showed better wound-healing effects than did the polyurethane foam and no dressing groups, and these differences were statistically significant. However, the differences between the AM groups were not statistically significant. Wound cultures showed higher infection rates in the control and polyurethane foam groups compared with the other groups. Our study showed that fresh or acellular bovine AMs provided similar efficacy for wound healing as did the fresh human AMs.
在猪皮肤烧伤创面中，比较了新鲜人羊膜和牛羊膜、脱细胞牛羊膜对伤口愈合的影响。选择6头猪进行研究，用数控铝热块在它们身上造成深二度接触性烧伤。然后，我们用新鲜人羊膜和牛羊膜、脱细胞牛羊膜、聚氨酯泡沫或不进行包扎，对部分伤口进行包扎。我们对猪进行了以下评估：（1）上皮化速率；（2）组织学分级；（3）感染情况。我们发现，羊膜组的伤口愈合效果优于聚氨酯泡沫组和不包扎组，且这些差异具有统计学意义。然而，羊膜组之间的差异无统计学意义。伤口培养显示，与其他组相比，对照组和聚氨酯泡沫组的感染率更高。我们的研究表明，新鲜或脱细胞牛羊膜在伤口愈合方面提供了与新鲜人羊膜相似的疗效。
