Eastgate J A, Symons J A, Wood N C, Capper S J, Duff G W
University of Edinburgh Department of Medicine, Northern General Hospital.
Br J Rheumatol. 1991 Aug;30(4):295-7. doi: 10.1093/rheumatology/30.4.295.
Interleukin-1-beta (IL-1 beta) has been implicated as an inflammatory mediator in rheumatoid arthritis (RA) but little is known about the related cytokine, IL-1 alpha, in this disease. IL-1 alpha has biological properties similar to IL-1 beta but, unlike IL-1 beta, remains mostly cell-associated. In this study plasma IL-1 alpha was measured by radioimmunoassay in patients with RA and in healthy controls. Plasma levels were compared with conventional measures of disease activity. The mean levels in the two groups were not significantly different and, within the patient group (n = 53), the only significant cross-sectional correlation was between plasma IL-1 alpha and ESR. In longitudinal studies, some individual patients had plasma IL-1 alpha levels that correlated with different measures of disease activity. We conclude that while IL-1 alpha may be involved in the immunopathogenesis of RA, its measurement in plasma seems to offer little of clinical value.
白细胞介素-1β（IL-1β）被认为是类风湿性关节炎（RA）中的一种炎症介质，但对于该疾病中相关细胞因子白细胞介素-1α（IL-1α）的了解却很少。IL-1α具有与IL-1β相似的生物学特性，但与IL-1β不同的是，它大多仍与细胞相关。在本研究中，通过放射免疫分析法对RA患者和健康对照者的血浆IL-1α进行了测量。将血浆水平与疾病活动的传统指标进行了比较。两组的平均水平无显著差异，在患者组（n = 53）中，唯一显著的横断面相关性是血浆IL-1α与红细胞沉降率（ESR）之间的相关性。在纵向研究中，一些个体患者的血浆IL-1α水平与不同的疾病活动指标相关。我们得出结论，虽然IL-1α可能参与RA的免疫发病机制，但其血浆测量似乎几乎没有临床价值。
