Armstrong J A, Evans A S, Rao N, Ho M
Infect Immun. 1976 Oct;14(4):970-5. doi: 10.1128/iai.14.4.970-975.1976.
Cytomegalovirus (CMV) infections are common in renal transplant recipients. We studied 23 recipients prospectively to determine whether infections by other herpes-group and non-herpes-group viruses were also present. Sera, obtained at the time of surgery and periodically thereafter, were tested for antibody to CMV, herpes simplex virus (HSV), Epstein-Barr virus (EBV), parainfluenza viruses types 1, 2, and 3, and the viruses of measles and rubella. We found no evidence of an unusual incidence of primary or secondary infection by the non-herpesviruses tested. Rises to CMV, HSV, and EBV antibody titers occurred in 43, 38, and 32% of patients, respectively. All serological rises to herpes-group viruses occurred in patients seropositive at the time of transplantation, with the exception of three patients who experienced primary CMV infections. We conclude that reactivation of all herpes-group viruses tested may occur in transplant recipients. Morbidity was associated only with primarly CMV infection.
巨细胞病毒（CMV）感染在肾移植受者中很常见。我们对23名受者进行了前瞻性研究，以确定是否也存在其他疱疹病毒组和非疱疹病毒组病毒的感染。在手术时及术后定期采集血清，检测针对CMV、单纯疱疹病毒（HSV）、EB病毒（EBV）、1型、2型和3型副流感病毒以及麻疹和风疹病毒的抗体。我们没有发现所检测的非疱疹病毒原发性或继发性感染发生率异常的证据。CMV、HSV和EBV抗体滴度升高的患者分别占43%、38%和32%。除了3名发生原发性CMV感染的患者外，所有疱疹病毒组病毒的血清学升高均发生在移植时血清阳性的患者中。我们得出结论，所检测的所有疱疹病毒组病毒在移植受者中都可能发生再激活。发病率仅与原发性CMV感染有关。
