Andersson Ingvar, Ikeda Debra M, Zackrisson Sophia, Ruschin Mark, Svahn Tony, Timberg Pontus, Tingberg Anders
Diagnostic Centre of Imaging and Functional Medicine, Malmö University Hospital, SE-205 02, Malmö, Sweden.
Eur Radiol. 2008 Dec;18(12):2817-25. doi: 10.1007/s00330-008-1076-9. Epub 2008 Jul 19.
The main purpose was to compare breast cancer visibility in one-view breast tomosynthesis (BT) to cancer visibility in one- or two-view digital mammography (DM). Thirty-six patients were selected on the basis of subtle signs of breast cancer on DM. One-view BT was performed with the same compression angle as the DM image in which the finding was least/not visible. On BT, 25 projections images were acquired over an angular range of 50 degrees, with double the dose of one-view DM. Two expert breast imagers classified one- and two-view DM, and BT findings for cancer visibility and BIRADS cancer probability in a non-blinded consensus study. Forty breast cancers were found in 37 breasts. The cancers were rated more visible on BT compared to one-view and two-view DM in 22 and 11 cases, respectively, (p < 0.01 for both comparisons). Comparing one-view DM to one-view BT, 21 patients were upgraded on BIRADS classification (p < 0.01). Comparing two-view DM to one-view BT, 12 patients were upgraded on BIRADS classification (p < 0.01). The results indicate that the cancer visibility on BT is superior to DM, which suggests that BT may have a higher sensitivity for breast cancer detection.
主要目的是比较单视图乳腺断层合成（BT）中乳腺癌的可视性与单视图或双视图数字乳腺摄影（DM）中癌症的可视性。基于DM上乳腺癌的细微迹象选择了36例患者。单视图BT的压迫角度与发现病变最少/不可见的DM图像相同。在BT上，在50度的角度范围内采集25幅投影图像，剂量是单视图DM的两倍。在一项非盲法的一致性研究中，两名专业乳腺成像专家对单视图和双视图DM以及BT上癌症的可视性和BIRADS癌症概率进行分类。在37个乳房中发现了40例乳腺癌。与单视图和双视图DM相比，分别有22例和11例癌症在BT上的可视性更高（两种比较的p值均<0.01）。将单视图DM与单视图BT进行比较，21例患者的BIRADS分类得到升级（p<0.01）。将双视图DM与单视图BT进行比较，12例患者的BIRADS分类得到升级（p<0.01）。结果表明，BT上癌症的可视性优于DM，这表明BT对乳腺癌检测可能具有更高的敏感性。
