Lewis F W, Warren G H, Goff J S
University of Colorado Health Sciences Center, Denver.
Dig Dis Sci. 1991 Aug;36(8):1161-3. doi: 10.1007/BF01297466.
We present a case of collagenous colitis with evidence of terminal ileal involvement. The patient suffered from chronic watery diarrhea of three months' duration, and colonoscopy revealed a normal endoscopic appearance. Histologic examination of biopsies revealed a broad subepithelial band of collagen, with similar histologic findings in the terminal ileum. Additionally, the patient exhibited abnormalities of d-xylose and vitamin B12 absorption, although there were no clinical signs of malabsorption. Biopsy of the proximal small intestine was normal. The significance of these findings for the definition of the clinicopathologic entity of collagenous colitis and its pathogenesis are discussed.
我们报告一例伴有回肠末端受累证据的胶原性结肠炎病例。该患者患有持续三个月的慢性水样腹泻，结肠镜检查显示内镜外观正常。活检组织学检查发现上皮下有一条宽阔的胶原带，回肠末端也有类似的组织学表现。此外，尽管没有吸收不良的临床症状，但患者的d-木糖和维生素B12吸收出现异常。近端小肠活检正常。本文讨论了这些发现对于胶原性结肠炎临床病理实体定义及其发病机制的意义。
