Fernández Pablo, Ott Albrecht
Experimentalphysik I, Physikalisches Institut, Universität Bayreuth, Bayreuth, Germany.
Phys Rev Lett. 2008 Jun 13;100(23):238102. doi: 10.1103/PhysRevLett.100.238102.
Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the complex rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic kinematic hardening. Despite the complexity of the living cell, its mechanical properties can be cast into simple, well-defined rules. Our results reveal the key role of crosslink slippage in determining mechanical cell strength and robustness.
细胞力学特性是生物体的基础，但目前仍了解甚少。我们报告了一个关于单个成纤维细胞复杂流变学的全面唯象学框架：弹性硬化和粘塑性运动硬化的叠加。尽管活细胞很复杂，但其力学特性可以归结为简单、明确的规则。我们的结果揭示了交联滑移在决定细胞机械强度和稳健性方面的关键作用。
