Reddy D R, Prassad V S, Das U N
Departments of Neurosurgery and Internal Medicine, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, India.
J Clin Neurosci. 1998 Jan;5(1):36-9. doi: 10.1016/s0967-5868(98)90199-0.
In vitro and in vivo studies have shown that gamma-leinolenic acid (GLA) can selectively kill tumour cells without harming normal cells. In view of this we have investigated the effect of intratumoural injection of GLA in intracranial gliomas, after reconfirmation of the safety of the drug on normal dog brain (n = 3). Fourteen patients underwent neurosurgical decompression along with placement of a catheter into the tumour bed. At the end of 1 week following surgery the patients were injected with 1 mg of GLA in sterile saline into the tumour bed daily for 10 days through the reservoir placed in the bone flap. Repeat computed tomography scans were obtained both before and after the GLA therapy with and without contrast administration. Necrosis and regression of the tumour have been observed, with reduction in mass effect and shift of midline structures. Two years' follow-up reveals that GLA is safe and tumour recurrence may be less in treated patients.
体外和体内研究表明，γ-亚麻酸（GLA）可选择性杀死肿瘤细胞而不损害正常细胞。鉴于此，在再次确认该药物对正常犬脑（n = 3）的安全性后，我们研究了瘤内注射GLA对颅内胶质瘤的影响。14例患者接受了神经外科减压手术，并在肿瘤床放置了导管。术后1周结束时，通过置于骨瓣中的储液器，每天向肿瘤床注射1 mg溶于无菌盐水中的GLA，持续10天。在GLA治疗前后均进行了增强和未增强的计算机断层扫描。观察到肿瘤坏死和消退，占位效应减轻，中线结构移位。两年的随访显示，GLA是安全的，接受治疗的患者肿瘤复发可能较少。
