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一些新型脂肪酸类似物的合成与表征：对其抗人肺癌细胞系活性的初步研究。

Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line.

机构信息

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Udhagamandalam, Rock lands, Ooty 643 001, Tamilnadu, India.

出版信息

Lipids Health Dis. 2013 Mar 28;12:45. doi: 10.1186/1476-511X-12-45.

DOI:10.1186/1476-511X-12-45
PMID:23537396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3621780/
Abstract

BACKGROUND

Preparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity.

METHODS

Gamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3,4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro.

RESULTS

Compound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.

摘要

背景

具有细胞毒性的新型杂环化合物的制备，这些化合物具有长链烷基和烯基。

方法

从微藻螺旋藻中分离出多不饱和脂肪酸γ-亚麻酸和饱和脂肪酸硬脂酸。合成了一些具有 1,3,4-噁二唑和 1,2,4-三唑的新型γ-亚麻酸和硬脂酸类似物，并通过红外光谱、1H NMR、13C NMR 和质谱分析进行了表征。通过体外 A-549 细胞生长抑制评估这些化合物的细胞毒性。

结果

化合物 1 和 3 对人肺癌 A-549 细胞系表现出相当的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a21c/3621780/4148dff3adf9/1476-511X-12-45-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a21c/3621780/2cfb28ed8081/1476-511X-12-45-i1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a21c/3621780/4148dff3adf9/1476-511X-12-45-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a21c/3621780/2cfb28ed8081/1476-511X-12-45-i1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a21c/3621780/4148dff3adf9/1476-511X-12-45-1.jpg

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