Lee Jin Young, Kim Yeon Kyung, Seo Jin Young, Choi Chong Won, Hwang Jae Sung, Lee Byeong Gon, Chang Ih Seop, Chung Jin Ho
Skin Research Institute, Amorepacific Corporation/R&D Center, Yongin-si, Gyeonggi-do, Republic of Korea.
J Dermatol Sci. 2008 May;50(2):99-107. doi: 10.1016/j.jdermsci.2007.11.010. Epub 2008 Jan 16.
Although wrinkling is the most obvious sign of aged skin, the detailed pathomechanism of wrinkle development has not been elucidated.
In this study, we investigated the role of elastic fibers in the formation of skin wrinkles.
Loss of elastic fibers was measured quantitatively in the facial skins of subjects representing seven decades, and then compared with wrinkle severities. We also investigated whether topical retinoic acid treatment to photoaged human skin can restore destroyed elastic fiber, and the correlation between wrinkle improvement with increase in elastic fibers in RA-treated facial skin.
We found a significant correlation between decreases in the length, width, number and total area of oxytalan fibers and wrinkle severity. Furthermore, we found that topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated and restored elastic fibers, and that there was a significant positive correlation between the amount of newly regenerated elastic fiber and the wrinkle improvement caused by retinoic acid.
Our results provide an objective insight into the role of elastic fibers in skin wrinkle formation by providing a quantitative correlation between changes in oxytalan fibers and the severity of skin wrinkling.
尽管皱纹是皮肤老化最明显的迹象，但皱纹形成的详细病理机制尚未阐明。
在本研究中，我们调查了弹性纤维在皮肤皱纹形成中的作用。
对代表七个年龄段的受试者面部皮肤中的弹性纤维损失进行定量测量，然后与皱纹严重程度进行比较。我们还研究了外用维甲酸治疗光老化人类皮肤是否能恢复被破坏的弹性纤维，以及维甲酸治疗的面部皮肤中弹性纤维增加与皱纹改善之间的相关性。
我们发现氧化弹性纤维的长度、宽度、数量和总面积的减少与皱纹严重程度之间存在显著相关性。此外，我们发现向长期光损伤皮肤局部应用维甲酸（0.025%）可使弹性纤维再生并恢复，并且新再生的弹性纤维数量与维甲酸引起的皱纹改善之间存在显著正相关。
我们的结果通过提供氧化弹性纤维变化与皮肤皱纹严重程度之间的定量相关性，对弹性纤维在皮肤皱纹形成中的作用提供了客观见解。
