Heilmann K L, Borchard F
Institute of Pathology, Municipal Hospital, Landshut, West Germany.
Gut. 1991 Feb;32(2):137-40. doi: 10.1136/gut.32.2.137.
An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients (87.2%) complaining of upper abdominal discomfort. Five patients (12.8%) had chronic gastritis and 34 (87.2%) chronic active gastritis. The organisms were seen by light microscopy deep in the gastric foveolae and intracellularly. The scanning and transmission electron microscopic findings show bacteria which invade and damage gastric mucosal cells. These organisms are similar to the spiral shaped bacteria found in the stomachs of cats and dogs and non-human primates. In eight patients organisms were not detected after four weeks of treatment with bismuth salts. The disappearance of the organisms coincided with resolution of the chronic active gastritis and the symptoms.
在胃活检标本中对幽门螺杆菌进行密集的组织学检查时，发现了人类胃黏膜中的其他螺旋形细菌。报告了34例（87.2%）主诉上腹部不适患者的临床和形态学结果（占观察期内所有胃活检的0.25%）。5例（12.8%）患有慢性胃炎，34例（87.2%）患有慢性活动性胃炎。这些微生物在胃小凹深部和细胞内通过光学显微镜可见。扫描和透射电子显微镜检查结果显示，这些细菌会侵入并损害胃黏膜细胞。这些微生物与在猫、狗和非人类灵长类动物胃中发现的螺旋形细菌相似。8例患者在使用铋盐治疗四周后未检测到微生物。微生物的消失与慢性活动性胃炎及症状的缓解同时出现。
