Baró Eva, Carulla Joan, Cassinello Javier, Colomer Ramón, Mata Jesús García, Gascón Pere, Gasquet José Antonio, Herdman Michael, Rodríguez César A, Sánchez Jordi, Valentín Vicente
3D Health Research, Barcelona, Spain.
Value Health. 2009 Jan-Feb;12(1):130-8. doi: 10.1111/j.1524-4733.2008.00426.x. Epub 2008 Jul 18.
Existing instruments that measure the impact of cancer-related fatigue on health-related quality of life do not usually incorporate the attitudes, beliefs and perspectives of patients. This study aimed to develop an instrument to measure the impact of cancer-related fatigue on the health-related quality of life of cancer patients.
Items were generated from a literature review, focus groups of cancer patients and meetings with oncologists. Potential items were administered to cancer patients to facilitate item reduction, which was based on clinimetric and psychometric analyses and qualitative criteria. A preliminary assessment of feasibility, reliability and validity of the retained items was performed.
An initial pool of 75 items was administered to 238 cancer patients. Fifty items were eliminated after statistical analysis and 13 in response to expert opinion, resulting in a provisional instrument with 12 items in 3 dimensions. These displayed acceptable internal consistency (Cronbach's alpha, 0.78-0.92) and their overall score was associated with fatigue intensity, extent of disease, intention of treatment and need of caregivers.
The newly developed questionnaire, which measures the impact of cancer-related fatigue on oncology patients, has shown satisfactory feasibility, reliability and validity.
现有的测量癌症相关疲劳对健康相关生活质量影响的工具通常未纳入患者的态度、信念和观点。本研究旨在开发一种工具，以测量癌症相关疲劳对癌症患者健康相关生活质量的影响。
通过文献综述、癌症患者焦点小组讨论以及与肿瘤学家的会议生成条目。将潜在条目施用于癌症患者以促进条目筛选，筛选基于临床测量学和心理测量学分析以及定性标准。对保留的条目进行了可行性、信度和效度的初步评估。
向238名癌症患者施测了初始的75个条目的题库。经统计分析后剔除了50个条目，根据专家意见又剔除了13个条目，最终形成了一个包含12个条目、3个维度的临时工具。这些条目显示出可接受的内部一致性（Cronbach's α系数，0.78 - 0.92），其总分与疲劳强度、疾病程度、治疗意向和护理需求相关。
新开发的用于测量癌症相关疲劳对肿瘤患者影响的问卷，已显示出令人满意的可行性、信度和效度。
