人体运动相关的气道血流变化：与心输出量和通气变化的关系。
Exercise-related change in airway blood flow in humans: relationship to changes in cardiac output and ventilation.
作者信息
Morris Norman R, Ceridon Maile L, Beck Kenneth C, Strom Nicholas A, Schneider Donald A, Mendes Eliana S, Wanner Adam, Johnson Bruce D
机构信息
School of Physiotherapy and Exercise Science, Griffith University, Gold Coast Campus, Qld 4222, Australia.
出版信息
Respir Physiol Neurobiol. 2008 Aug 31;162(3):204-9. doi: 10.1016/j.resp.2008.06.020. Epub 2008 Jul 5.
This study examined the relationship between airway blood flow (Q(aw)), ventilation (V(E)) and cardiac output (Q(tot)) during exercise in healthy humans (n=12, mean age 34+/-11 yr). Q(aw) was estimated from the uptake of the soluble gas dimethyl ether while V(E) and Q(tot) were measured using open circuit spirometry. Measurements were made prior to and during exercise at 34+/-5 W (Load 1) and 68+/-10 W (Load 2) and following the cessation of exercise (recovery). Q(aw) increased in a stepwise fashion (P<0.05) from rest (52.8+/-19.5 microl min(-1) ml(-1)) to exercise at Load 1 (67.0+/-20.3 microl min(-1) ml(-1)) and Load 2 (84.0+/-22.9 microl min(-1) ml(-1)) before returning to pre-exercise levels in recovery (51.7+/-13.2 microl min(-1) ml(-1)). Q(aw) was positively correlated with both Q(tot) (r=0.58, P<0.01) and V(E) (r=0.50, P<0.01). These results demonstrate that the increase in Q(aw) is linked to an exercise related increase in both Q(tot) and V(E) and may be necessary to prevent excessive airway cooling and drying.
本研究调查了健康人（n = 12，平均年龄34±11岁）运动期间气道血流量（Q(aw)）、通气量（V(E)）和心输出量（Q(tot)）之间的关系。通过可溶性气体二甲醚的摄取量估算Q(aw)，同时使用开路肺量计测量V(E)和Q(tot)。在运动前、运动期间34±5瓦（负荷1）和68±10瓦（负荷2）以及运动停止后（恢复）进行测量。Q(aw)以逐步方式增加（P<0.05），从静息时（52.8±19.5微升·分钟⁻¹·毫升⁻¹）增加到负荷1运动时（67.0±20.3微升·分钟⁻¹·毫升⁻¹）和负荷2运动时（84.0±22.9微升·分钟⁻¹·毫升⁻¹），然后在恢复时回到运动前水平（51.7±13.2微升·分钟⁻¹·毫升⁻¹）。Q(aw)与Q(tot)（r = 0.58，P<0.01）和V(E)（r = 0.50，P<0.01）均呈正相关。这些结果表明，Q(aw)的增加与Q(tot)和V(E)的运动相关增加有关，可能是防止气道过度冷却和干燥所必需的。
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