Radespiel-Tröger M, Meyer M, Pfahlberg A, Lausen B, Uter W, Gefeller O
Population-based Cancer Registry Bavaria, Registration office, Erlangen, Germany.
Int Arch Occup Environ Health. 2009 Feb;82(3):357-63. doi: 10.1007/s00420-008-0342-0. Epub 2008 Jul 23.
To analyse the association between occupational ultraviolet (UV) light exposure and skin cancer (basal cell carcinoma, BCC; squamous cell carcinoma, SCC; cutaneous malignant melanoma, CMM) based on data from the Bavarian population-based cancer registry.
The population-based cancer registry of Bavaria (Germany) provided data on incident cases of BCC, SCC, and CMM, respectively, during the period 2001 until 2005. Eleven Bavarian districts with complete skin cancer registration were included in this analysis based on 2,156,336 person years. Cases were assigned to "indoor", "mixed indoor/outdoor", and "outdoor" exposure categories according to their job title. We computed age-specific and age-adjusted incidence rates of BCC (n = 1,641), SCC (n = 499), and CMM (n = 454) by work type, and the relative risk (RR) of skin cancer occurrence for "outdoor" and "mixed indoor/outdoor" workers, respectively, compared to "indoor" workers.
The risk of BCC was substantially elevated in male (RR, 2.9; 95% CI, 2.2-3.9) and female (RR, 2.7; 95% CI, 1.8-4.1) outdoor workers compared to male and female indoor workers, respectively. We also found an elevated risk of similar magnitude for SCC in male (RR, 2.5; 95% CI, 1.4-4.7) and female (RR, 3.6; 95% CI, 1.6-8.1) outdoor workers compared to male and female indoor workers, respectively. CMM risk was not significantly associated with outdoor work.
Our study confirms previous reports on the increased risk of BCC and SCC in outdoor workers compared to indoor workers.
基于巴伐利亚州人群癌症登记处的数据，分析职业性紫外线暴露与皮肤癌（基底细胞癌、BCC；鳞状细胞癌、SCC；皮肤恶性黑色素瘤、CMM）之间的关联。
德国巴伐利亚州的人群癌症登记处提供了2001年至2005年期间BCC、SCC和CMM的发病病例数据。基于2156336人年，本分析纳入了11个皮肤癌登记完整的巴伐利亚地区。根据病例的职业将其分为“室内”、“室内/室外混合”和“室外”暴露类别。我们按工作类型计算了BCC（n = 1641）、SCC（n = 499）和CMM（n = 454）的年龄特异性发病率和年龄调整发病率，以及“室外”和“室内/室外混合”工作者相对于“室内”工作者患皮肤癌的相对风险（RR）。
与男性和女性室内工作者相比，男性（RR，2.9；95%CI，2.2 - 3.9）和女性（RR，2.7；95%CI，1.8 - 4.1）室外工作者患BCC的风险显著升高。我们还发现，与男性和女性室内工作者相比，男性（RR，2.5；95%CI，1.4 - 4.7）和女性（RR，3.6；95%CI，1.6 - 8.1）室外工作者患SCC的风险也有类似程度的升高。CMM风险与室外工作无显著关联。
我们的研究证实了先前关于室外工作者患BCC和SCC风险高于室内工作者的报道。
