Lindelöf Bernt, Lapins Jan, Dal Henrik
Department of Medicine Dermatology and Venereology Unit, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Acta Derm Venereol. 2017 Jul 6;97(7):830-833. doi: 10.2340/00015555-2660.
Basal cell carcinoma (BCC) is the most common form of cancer worldwide. Exposure of the skin to ultraviolet (UV) radiation, from sunlight and other sources, is the most important risk factor. The aim of this large-scale case-control study was to determine which occupations are associated with increased risk of BCC in Sweden. The case cohort comprised 74,247 patients with BCC and the control cohort comprised 574,055 subjects linked to population-based registers. Compared with the occupational category of farmers, foresters and gardeners we observed elevated risks of BCC for almost all occupational categories studied. Legal workers with odds ratio (OR) 2.69 (95% confidence interval (CI) 2.36-3.06), dentists OR 2.69 (95% CI 2.35-3.08) and physicians OR 2.47 (95% CI 2.24-2.74) had the highest risk for both sexes taken together. In conclusion, there appears to have been a change in the risk of BCC from outdoor to indoor occupations in Sweden, possibly related to exposure to UV radiation during leisure activities exceeding occupational sun exposure as the main cause of BCC in Sweden.
基底细胞癌（BCC）是全球最常见的癌症形式。皮肤暴露于来自阳光和其他来源的紫外线（UV）辐射是最重要的风险因素。这项大规模病例对照研究的目的是确定瑞典哪些职业与基底细胞癌风险增加有关。病例队列包括74247例基底细胞癌患者，对照队列包括与基于人群的登记册相关联的574055名受试者。与农民、林业工人和园艺工人的职业类别相比，我们观察到几乎所有研究的职业类别患基底细胞癌的风险都有所升高。男女合计，法律工作者的优势比（OR）为2.69（95%置信区间（CI）2.36 - 3.06），牙医为2.69（95%CI 2.35 - 3.08），医生为2.47（95%CI 2.24 - 2.74），风险最高。总之，在瑞典，基底细胞癌的风险似乎已从户外职业转向室内职业，这可能与休闲活动期间的紫外线辐射暴露超过职业性阳光暴露有关，而职业性阳光暴露是瑞典基底细胞癌的主要原因。
