Pazzaglia G, Sack R B, Salazar E, Yi A, Chea E, Leon-Barua R, Guerrero C E, Palomino J
U.S. Naval Medical Research Institute Detachment, Department of Pediatrics, Hospital Nacional Cayetano Heredia, Peru.
J Clin Microbiol. 1991 Jun;29(6):1151-6. doi: 10.1128/jcm.29.6.1151-1156.1991.
Rectal swabs from 391 infants less than 18 months of age who were hospitalized with acute diarrhea and from 138 similarly aged healthy infants were examined for the etiologic agents of diarrhea. Aeromonas spp. were recovered from 205 of 391 (52.4%) diarrheic patients, whereas they were recovered from 12 of 138 (8.7%) controls (P less than 10(-11). Among the 205 Aeromonas-positive diarrheic patients, 118 (57.6%) were found to be coinfected with other common enteropathogens. Of the 164 Aeromonas-positive initial diarrheic specimens, 82 (50.0%) had one or more other enteropathogens present; 30 patients were coinfected with rotavirus, 20 with enterotoxigenic Escherichia coli, 16 with Campylobacter spp., 14 with Shigella spp., 13 with enteropathogenic E. coli, 4 with Vibrio spp., 1 with Salmonella spp., and 1 with Plesiomonas spp. of Aeromonas strains from cases compared with that from controls supports an etiologic role for this organism. However, frequent concomitant infections with other well-recognized enteropathogens and a lack of disease correlation with common Aeromonas phenotypes suggest that only a subset of Aeromonas strains may be diarrhea causing and that such strains may be common to several of the existing species.
对391名18个月以下因急性腹泻住院的婴儿以及138名年龄相仿的健康婴儿进行直肠拭子检查，以确定腹泻的病原体。在391名腹泻患者中，有205名（52.4%）检出气单胞菌属，而在138名对照者中，有12名（8.7%）检出气单胞菌属（P<10⁻¹¹）。在205名气单胞菌阳性的腹泻患者中，有118名（57.6%）被发现同时感染了其他常见肠道病原体。在164份气单胞菌阳性的初次腹泻标本中，有82份（50.0%）存在一种或多种其他肠道病原体；30名患者同时感染轮状病毒，20名感染产肠毒素大肠杆菌，16名感染弯曲菌属，14名感染志贺菌属，13名感染致病性大肠杆菌，4名感染弧菌属，1名感染沙门菌属，1名感染邻单胞菌属。病例中气单胞菌菌株与对照中气单胞菌菌株的比较结果支持该菌具有病因学作用。然而，频繁同时感染其他公认的肠道病原体以及缺乏与常见气单胞菌表型的疾病相关性表明，只有一部分气单胞菌菌株可能导致腹泻，并且这些菌株可能在现有的几个菌种中都很常见。
