重症肌无力抗乙酰胆碱受体抗体检测的不足之处。
Deficiencies in anti-acetylcholine receptor antibody measurement in myasthenia gravis.
作者信息
Clarke C E, Shepherd D I, Yuill G M, Smaje J C, Wilson P B
机构信息
Department of Neurology, North Manchester General Hospital, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1991 May;54(5):454-6. doi: 10.1136/jnnp.54.5.454.
Abstract
In a retrospective case note study of 86 patients with myasthenia gravis, 60 had an anti-acetylcholine receptor antibody assay performed by the regional immunology laboratory. Antibody was detected in 38% which compares with 66-93% in other series. Whilst the use of staphylococcal protein A to precipitate the antibody-receptor complex, rather than anti-human immunoglobulin, may be partly responsible for this low sensitivity, other methodological problems are likely to exist. It is suggested that this potentially critical assay becomes a subject for regular audit.
摘要
在一项对86例重症肌无力患者的回顾性病例记录研究中，60例患者接受了地区免疫学实验室进行的抗乙酰胆碱受体抗体检测。检测到抗体的患者占38%，而其他系列研究中的比例为66%-93%。虽然使用葡萄球菌蛋白A沉淀抗体-受体复合物而非抗人免疫球蛋白可能是导致这种低敏感性的部分原因，但可能还存在其他方法学问题。建议将这项可能至关重要的检测作为定期审核的对象。
相似文献
1
Deficiencies in anti-acetylcholine receptor antibody measurement in myasthenia gravis.重症肌无力抗乙酰胆碱受体抗体检测的不足之处。
J Neurol Neurosurg Psychiatry. 1991 May;54(5):454-6. doi: 10.1136/jnnp.54.5.454.
2
A solid-phase enzyme immunoassay for anti-acetylcholine receptor antibody in myasthenia gravis patients.重症肌无力患者抗乙酰胆碱受体抗体的固相酶免疫测定法。
J Immunol Methods. 1984 Oct 26;73(2):267-72. doi: 10.1016/0022-1759(84)90401-0.
3
Analysis of false negative results in the immunoassay for anti-acetylcholine receptor antibodies in myasthenia gravis.重症肌无力抗乙酰胆碱受体抗体免疫测定中假阴性结果的分析。
Clin Immunol Immunopathol. 1984 May;31(2):191-201. doi: 10.1016/0090-1229(84)90239-3.
4
Are spontaneous anti-idiotypic antibodies against anti-acetylcholine receptor antibodies present in myasthenia gravis?重症肌无力患者体内是否存在针对抗乙酰胆碱受体抗体的自发性抗独特型抗体？
J Autoimmun. 1988 Apr;1(2):131-42. doi: 10.1016/0896-8411(88)90021-2.
5
Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays.乙酰胆碱受体抗体作为重症肌无力的诊断检测：153例确诊病例及2967次诊断检测的结果
J Neurol Neurosurg Psychiatry. 1985 Dec;48(12):1246-52. doi: 10.1136/jnnp.48.12.1246.
6
Acetylcholine receptor antibody in patients with myasthenia gravis.重症肌无力患者的乙酰胆碱受体抗体
Asian Pac J Allergy Immunol. 1986 Dec;4(2):101-5.
7
8
Bread-and-butter in diagnosis of myasthenia gravis.重症肌无力诊断的关键要点。
Arch Neurol. 2005 Dec;62(12):1939; author reply 1939-40. doi: 10.1001/archneur.62.12.1939-a.
9
Enzyme-linked immunosorbent assay for antibody against the nicotinic acetylcholine receptor in human myasthenia gravis.人重症肌无力中抗烟碱型乙酰胆碱受体抗体的酶联免疫吸附测定
Ann Neurol. 1984 Feb;15(2):195-200. doi: 10.1002/ana.410150214.
10
Experimental myasthenia gravis: isolation and quantitative assay of anti-acetylcholine receptor antibody protein concentration in sera of rabbits immunized with Narke acetylcholine receptor.实验性重症肌无力：用日本电鳐乙酰胆碱受体免疫的家兔血清中抗乙酰胆碱受体抗体蛋白浓度的分离与定量测定
Exp Neurol. 1980 Jun;68(3):512-20. doi: 10.1016/0014-4886(80)90105-3.
引用本文的文献
1
Anti-acetylcholine receptor antibody measurement in myasthenia gravis.重症肌无力中抗乙酰胆碱受体抗体的检测
J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):115-6. doi: 10.1136/jnnp.56.1.115-b.
本文引用的文献
1
Humoral immunity in myasthenia gravis: biochemical characterization of acquired antireceptor antibodies and clinical correlations.重症肌无力中的体液免疫：获得性抗受体抗体的生化特征及临床相关性
Ann Neurol. 1981 Nov;10(5):437-47. doi: 10.1002/ana.410100506.
2
Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis.重症肌无力疾病异质性的临床、病理、HLA抗原及免疫学证据
Brain. 1980 Sep;103(3):579-601. doi: 10.1093/brain/103.3.579.
3
The natural course of myasthenia gravis and effect of therapeutic measures.重症肌无力的自然病程及治疗措施的效果。
Ann N Y Acad Sci. 1981;377:652-69. doi: 10.1111/j.1749-6632.1981.tb33764.x.
4
Properties and serum levels of specific populations of anti-acetylcholine receptor antibodies in myasthenia gravis.重症肌无力中抗乙酰胆碱受体抗体特定群体的特性及血清水平
Ann N Y Acad Sci. 1981;377:307-15. doi: 10.1111/j.1749-6632.1981.tb33740.x.
5
The human acetylcholine receptor antibody: studies of kinetic and biochemical properties and the reaction with anti-idiotypic antibodies.人乙酰胆碱受体抗体：动力学和生化特性研究以及与抗独特型抗体的反应
Ann N Y Acad Sci. 1981;377:125-42. doi: 10.1111/j.1749-6632.1981.tb33728.x.
6
Anti-acetylcholine receptor antibodies in myasthenia gravis. Part 1. Relation to clinical parameters in 250 patients.重症肌无力中的抗乙酰胆碱受体抗体。第1部分。与250例患者临床参数的关系。
J Neurol Sci. 1983 Mar;58(3):357-70. doi: 10.1016/0022-510x(83)90095-3.
7
8
Clinical electrophysiology in myasthenia gravis.重症肌无力的临床电生理学
J Neurol Neurosurg Psychiatry. 1980 Jul;43(7):622-33. doi: 10.1136/jnnp.43.7.622.
9
Myasthenia gravis and myasthenic syndromes.重症肌无力和肌无力综合征。
Ann Neurol. 1984 Nov;16(5):519-34. doi: 10.1002/ana.410160502.
10
Myasthenia gravis: evaluation of treatment in 1,355 patients.重症肌无力：1355例患者的治疗评估
Neurology. 1966 May;16(5):431-9. doi: 10.1212/wnl.16.5.431.
Zotero 插件