Margetts L, Carr A, McFadyen G, Lambert A
Derriford Hospital, Directorate of Anaesthesia, Theatres and Pain Services, Plymouth, UK.
Eur J Anaesthesiol. 2008 Dec;25(12):1009-13. doi: 10.1017/S0265021508004833. Epub 2008 Jul 24.
To establish whether caudal with ketamine or penile block provide superior postoperative analgesia for paediatric circumcision.
This was a single centre, prospective, randomized, controlled, double-blind trial. Forty males (aged between 18 months and 16 yr) were randomized to receive either a penile block using 0.25 mL kg(-1) 0.5% bupivacaine (Group P), or a caudal block using 0.5 mL kg(-1) 0.25% bupivacaine with 0.5 mg kg(-1) ketamine (Group C). All of them were given a standard anaesthetic and rectal paracetamol 40 mg kg(-1) and diclofenac 1-1.5 mg kg(-1). Postoperative pain scores were assessed in recovery and the time to first analgesia, micturition and walking were recorded.
There were no failures in either group. The time to first analgesia was longer in Group C (C median = 459 min, interquartile range 374-553 min; P median = 374 min, interquartile range 224-507 min; P < 0.05). There was a delay in time to walking in Group C (C median = 162 min, interquartile range 119-208 min; P median = 120 min, interquartile range 92-132 min; P < 0.05). There was no difference between the groups in time to waking or micturition, or the incidence of vomiting, abnormal behaviour or bleeding.
Caudal bupivacaine with ketamine and penile block both provide effective postoperative analgesia for circumcision when given with non-steroidal anti-inflammatory drugs. This study shows that caudal bupivacaine with ketamine provides a longer duration of analgesia than penile block, but also causes delay in walking.
确定氯胺酮骶管阻滞或阴茎阻滞是否能为小儿包皮环切术提供更优的术后镇痛效果。
这是一项单中心、前瞻性、随机、对照、双盲试验。40名男性患儿(年龄在18个月至16岁之间)被随机分为两组,一组接受使用0.25 mL/kg 0.5%布比卡因的阴茎阻滞(P组),另一组接受使用0.5 mL/kg 0.25%布比卡因加0.5 mg/kg氯胺酮的骶管阻滞(C组)。所有患儿均接受标准麻醉,并给予40 mg/kg直肠用对乙酰氨基酚和1 - 1.5 mg/kg双氯芬酸。在恢复过程中评估术后疼痛评分,并记录首次镇痛时间、排尿时间和行走时间。
两组均无阻滞失败情况。C组首次镇痛时间更长(C组中位数 = 459分钟,四分位间距374 - 553分钟;P组中位数 = 374分钟,四分位间距224 - 507分钟;P < 0.05)。C组行走时间延迟(C组中位数 = 162分钟,四分位间距119 - 208分钟;P组中位数 = 120分钟,四分位间距92 - 132分钟;P < 0.05)。两组在苏醒时间、排尿时间、呕吐发生率、异常行为或出血情况方面无差异。
当与非甾体类抗炎药联合使用时,氯胺酮骶管阻滞和阴茎阻滞均可为包皮环切术提供有效的术后镇痛。本研究表明,氯胺酮骶管阻滞比阴茎阻滞镇痛持续时间更长,但也会导致行走延迟。