Su Ta-Chen, Lin Lian-Yu, Baker Dean, Schnall Peter L, Chen Ming-Fong, Hwang Wen-Chang, Chen Chen-Fang, Wang Jung-Der
Department of Internal Medicine, National Taiwan University Hospital, Taiwan.
J Occup Health. 2008;50(5):380-6. doi: 10.1539/joh.l7056. Epub 2008 Jul 25.
Shift work has been associated with increased risk of cardiovascular disease. This study was designed to determine the hemodynamic effects of 12-hour (12-h) shifts, and changes in blood pressure (BP) and heart rate variability (HRV) during 36 h rest time following 12-h shifts. Fifteen male shift workers with a mean age of 32.9 yr were recruited from a semiconductor factory. Ambulatory BP (AmBP) monitoring was performed for a total of 48 h for each participant. Six workers were monitored for 48 h by Holter electrocardiogram on both the day and night shifts. Paired self-comparison was used to estimate the difference between two hourly measurements of 12-h BP, HR, and HRV using the same timetable intra-individually. We also applied mixed models to estimate the effects of 12-h shifts on the delayed recovery of BP and heart rate (HR) in six workers who completed 96-h AmBP monitoring, including a 48-h night shift-rest period and another day shift period. Results showed that 12-h night shift work gave a persistently elevated systolic and diastolic BP (SBP and DBP) and HR, and decreased HRV compared to 12-h day shift work with the corresponding resting time. In addition, there was delayed SBP and DBP recovery on the first 12-h rest time in night shift workers, which was further demonstrated on the second 12-h rest time after adjustment for possible confounders through mixed models. In conclusion, 12-h night shift work may elevate BP and HR and decrease HRV. It is also associated with delayed BP recovery.
轮班工作与心血管疾病风险增加有关。本研究旨在确定12小时轮班的血流动力学效应，以及12小时轮班后36小时休息时间内血压（BP）和心率变异性（HRV）的变化。从一家半导体工厂招募了15名平均年龄为32.9岁的男性轮班工人。对每位参与者进行了总共48小时的动态血压（AmBP）监测。6名工人在白班和夜班均通过动态心电图进行了48小时监测。采用配对自身比较法，使用相同的时间表在个体内估计12小时BP、心率（HR）和HRV每小时两次测量值之间的差异。我们还应用混合模型来估计12小时轮班对6名完成96小时AmBP监测的工人血压和心率延迟恢复的影响，包括48小时夜班休息期和另一个白班期。结果显示，与相应休息时间的12小时白班工作相比，12小时夜班工作导致收缩压和舒张压（SBP和DBP）以及心率持续升高，HRV降低。此外，夜班工人在第一个12小时休息时间出现SBP和DBP恢复延迟，通过混合模型对可能的混杂因素进行调整后，在第二个12小时休息时间进一步得到证实。总之，12小时夜班工作可能会升高血压和心率，降低HRV。它还与血压恢复延迟有关。
