Dobson Jon
Institute for Science & Technology in Medicine, Keele University, Thornburrow Drive, Harsthill, Stoke-on-Trent, UK.
Nat Nanotechnol. 2008 Mar;3(3):139-43. doi: 10.1038/nnano.2008.39.
By binding magnetic nanoparticles to the surface of cells, it is possible to manipulate and control cell function with an external magnetic field. The technique of activating cells with magnetic nanoparticles offers a means to isolate and explore cellular mechanics and ion channel activation to gain better understanding of these processes. Here, we go beyond using this technique as an investigative tool and focus on its potential to actively control cellular functions and processes with an eye towards biological and clinical applications. In particular, we focus on applications in tissue engineering and regenerative medicine.
通过将磁性纳米颗粒结合到细胞表面,可以利用外部磁场来操纵和控制细胞功能。用磁性纳米颗粒激活细胞的技术提供了一种手段,可用于分离和探索细胞力学以及离子通道激活,从而更好地理解这些过程。在这里,我们不仅仅将该技术用作一种研究工具,而是着眼于生物和临床应用,专注于其主动控制细胞功能和过程的潜力。特别是,我们专注于组织工程和再生医学方面的应用。