Katze Michael G, Fornek Jamie L, Palermo Robert E, Walters Kathie-Anne, Korth Marcus J
Department of Microbiology and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195-8070, USA.
Nat Rev Immunol. 2008 Aug;8(8):644-54. doi: 10.1038/nri2377.
Although often encoding fewer than a dozen genes, RNA viruses can overcome host antiviral responses and wreak havoc on the cells they infect. Some manage to evade host antiviral defences, whereas others elicit an aberrant or disproportional immune response. Both scenarios can result in the disruption of intracellular signalling pathways and significant pathology in the host. Systems-biology approaches are increasingly being used to study the processes of viral triggering and regulation of host immune responses. By providing a global and integrated view of cellular events, these approaches are beginning to unravel some of the complexities of virus-host interactions and provide new insights into how RNA viruses cause disease.
尽管RNA病毒通常编码的基因不到十二个，但它们能够克服宿主的抗病毒反应，并对其所感染的细胞造成严重破坏。一些病毒设法逃避宿主的抗病毒防御，而另一些则引发异常或过度的免疫反应。这两种情况都可能导致细胞内信号通路的破坏以及宿主出现严重病变。系统生物学方法越来越多地被用于研究病毒触发和调节宿主免疫反应的过程。通过提供细胞事件的全局和综合视图，这些方法开始揭示病毒与宿主相互作用的一些复杂性，并为RNA病毒如何引起疾病提供新的见解。
