RNA 病毒的感应：参与识别 RNA 病毒入侵的固有免疫受体综述。
Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion.
机构信息
Institute of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark.
出版信息
J Virol. 2012 Mar;86(6):2900-10. doi: 10.1128/JVI.05738-11. Epub 2012 Jan 18.
Abstract
Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.
摘要
在过去的十年中，我们对于先天免疫系统在识别和随后引发宿主对 RNA 病毒入侵的反应方面的作用的了解迅速增加。涉及的受体的描述以及它们用于感知病毒病原体相关分子模式的分子机制已经详细出现。这篇综述概述了我们目前对用于检测 RNA 病毒入侵的受体、这些受体感知的分子结构以及涉及的下游信号通路的了解。
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