Pierce R O, Perry A
Department of Orthopaedic Surgery, Indiana University Medical Center, Indianapolis 46223.
J Natl Med Assoc. 1991 Jun;83(6):505-8.
Chronic alcoholics frequently have osteopenia. This usually leads to an increase in long bone fractures. The exact cause of these changes is unknown. They could be caused by a change in the calcium metabolism or a change in the organic phase of bone. To elucidate the exact mechanism by which these changes occur, the following study was done. Forty-six Sprague-Dawley rats were divided into four groups. Two groups received alcohol, and two groups served as control. One set of each group received a fracture to the leg in order to study any change that might occur in the organic phase of bone. Our findings in these animals demonstrated that alcohol causes osteopenia due to a change in calcium metabolism and does not appear to effect the organic phase of bone.
慢性酗酒者常常患有骨质减少。这通常会导致长骨骨折增加。这些变化的确切原因尚不清楚。它们可能是由钙代谢变化或骨有机相变化引起的。为了阐明这些变化发生的确切机制，进行了以下研究。46只斯普拉格-道利大鼠被分为四组。两组给予酒精，两组作为对照。每组中的一组腿部骨折，以便研究骨有机相可能发生的任何变化。我们在这些动物身上的研究结果表明，酒精会因钙代谢变化而导致骨质减少，且似乎不会影响骨有机相。
