Department of Infectious Disease Control, Faculty of Medicine, Oita University, Yufu 879-5593, Japan.
Department of Anatomy, Histology and Pharmacology, Universitas Airlangga, Surabaya 60131, Indonesia.
Toxins (Basel). 2021 Apr 28;13(5):315. doi: 10.3390/toxins13050315.
Although millions of people have been infected by (), only a small proportion of infected individuals will develop adverse outcomes, ranging from chronic gastritis to gastric cancer. Advanced development of the disease has been well-linked with chronic inflammation, which is significantly impacted by the adaptive and humoral immunity response. From the perspective of cellular immunity, this review aims to clarify the intricate axis between IL-17, IL-21, and IL-23 in -related diseases and the pathogenesis of inflammatory gastrointestinal diseases. CD4 helper T (Th)-17 cells, with the hallmark pleiotropic cytokine IL-17, can affect antimicrobial activity and the pathogenic immune response in the gut environment. These circumstances cannot be separated, as the existence of affiliated cytokines, including IL-21 and IL-23, help maintain Th17 and accommodate humoral immune cells. Comprehensive understanding of the dynamic interaction between molecular host responses in -related diseases and the inflammation process may facilitate further development of immune-based therapy.
尽管数百万人感染了 (), 但只有一小部分感染者会出现不良后果，从慢性胃炎到胃癌不等。疾病的晚期发展与慢性炎症密切相关，而慢性炎症又受到适应性和体液免疫反应的显著影响。从细胞免疫的角度来看，本综述旨在阐明与 () 相关疾病和炎症性胃肠道疾病发病机制相关的 IL-17、IL-21 和 IL-23 之间复杂的轴。辅助性 T 细胞 17(Th17) 细胞，其标志性的多效细胞因子 IL-17，可以影响肠道环境中的抗菌活性和致病免疫反应。这些情况是不可分割的，因为附属细胞因子的存在，包括 IL-21 和 IL-23，有助于维持 Th17 和适应体液免疫细胞。全面了解与 () 相关疾病中的分子宿主反应与炎症过程之间的动态相互作用，可能有助于进一步开发基于免疫的治疗方法。
