Increased IL-17A Serum Levels and Gastric Th17 Cells in -Infected Patients with Gastric Premalignant Lesions.

infection is characterized by an inflammatory infiltrate that might be an important antecedent of gastric cancer. The purpose of this study was to evaluate whether interleukin (IL)-17 inflammation is elicited by gastric T cells in patients with gastric intestinal metaplasia and dysplasia (IM/DYS). We also investigated the serum IL-17A levels in patients with gastric intestinal metaplasia and dysplasia, and patients with non-atrophic gastritis (NAG). the IL-17 cytokine profile of gastric T cells was investigated in six patients with IM/DYS and infection. Serum IL-17A levels were measured in 45 -infected IM/DYS patients, 45 -infected patients without IM/DYS and in 45 healthy controls (HC). gastric T cells from all IM/DYS patients with were able to proliferate in response to and to produce IL-17A. The Luminex analysis revealed that IL-17A levels were significantly increased in IM/DYS patients compared to healthy controls and to gastritis patients without IM/DYS (452.34 ± 369.13 pg/mL, 246.82 ± 156.06 pg/mL, 169.26 ± 73.82 pg/mL, respectively; < 0.01, < 0.05). the results obtained indicate that is able to drive gastric IL-17 inflammation in IM/DYS -infected patients, and that IL-17A serum levels are significantly increased in -infected patients with IM/DYS.