Andrasko Gary, Ryen Kelly
Optometry. 2008 Aug;79(8):444-54. doi: 10.1016/j.optm.2008.04.097.
Assessment of ocular responses associated with lens and contact lens solution combinations was undertaken to address recent reports of toxicity caused by lens solutions resulting in high levels of corneal staining.
Double-masked, randomized, crossover, clinical studies were conducted at one research site. Before wear, new lenses were soaked at least 12 hours in marketed lens care solutions. Unisol 4 Preservative Free Saline (Alcon Labs, Fort Worth, Texas) was also assessed and served as a control. Corneal staining [severity (0-4) and area (0-100%)] and comfort were evaluated.
The majority of observed staining was micropunctate. PureVision lenses in combination with the biguanide-preserved solutions resulted in excessive staining area at 2 hours (ReNu MultiPlus, 73%; Complete MoisturePlus, 48%; AQuify, 21%). Staining tended to decrease throughout the wearing day, but several biguanide solution/lens combinations continued to exhibit excessive staining at 4 hours. Similar to saline, Opti-Free Express and RepleniSH as well as Clear Care exhibited minimal staining area, averaging 7% or less at 2 hours across all lens brands. Subjective comfort tended to decrease with higher levels of corneal staining area.
Some solution/lens combinations may cause excessive corneal staining 2 to 4 hours after lens insertion. Patients with high levels of corneal staining may experience decreased comfort.
针对近期有关隐形眼镜护理液导致毒性并造成高水平角膜染色的报道，开展了与镜片和隐形眼镜护理液组合相关的眼部反应评估。
在一个研究地点进行了双盲、随机、交叉的临床研究。佩戴前，新镜片在市售的隐形眼镜护理液中浸泡至少12小时。还对无防腐剂的Unisol 4生理盐水（爱尔康实验室，得克萨斯州沃思堡）进行了评估并用作对照。评估角膜染色情况[严重程度（0 - 4级）和面积（0 - 100%）]以及舒适度。
观察到的染色大多为微点状。PureVision镜片与含双胍防腐剂的护理液组合在2小时时导致染色面积过大（ReNu MultiPlus为73%；Complete MoisturePlus为48%；AQuify为21%）。在整个佩戴日中，染色倾向于减少，但几种双胍护理液/镜片组合在4小时时仍表现出过大的染色面积。与生理盐水类似，Opti-Free Express、RepleniSH以及Clear Care的染色面积最小，在2小时时所有镜片品牌的平均染色面积为7%或更低。主观舒适度往往随着角膜染色面积的增加而降低。
一些护理液/镜片组合可能在镜片插入后2至4小时导致角膜过度染色。角膜染色程度高的患者可能会感到舒适度下降。
