Moore Andrew D, Björklund Asa K, Ekman Diana, Bornberg-Bauer Erich, Elofsson Arne
Evolutionary Bioinformatics, IEB, University of Münster, Hüfferstrasse 1, Münster, Germany.
Trends Biochem Sci. 2008 Sep;33(9):444-51. doi: 10.1016/j.tibs.2008.05.008. Epub 2008 Jul 24.
It has been known for the last couple of decades that proteins evolve partly through rearrangements of larger fragments, typically domains. These units are considered the basic modules of protein structure, evolution and function. In the last few years, the analysis of protein-domain rearrangements has provided us with functional and evolutionary insights and has aided improved functional predictions and domain assignments to previously uncharacterised genes and proteins. Although some mechanisms that govern modular rearrangements of protein domains have been uncovered, such as the addition or deletion of a single N- or C-terminal domain, much is still unknown about the genetics behind these arrangements.
在过去几十年里，人们已经知道蛋白质部分是通过较大片段（通常是结构域）的重排而进化的。这些单元被认为是蛋白质结构、进化和功能的基本模块。在过去几年中，对蛋白质结构域重排的分析为我们提供了功能和进化方面的见解，并有助于改进对以前未表征的基因和蛋白质的功能预测和结构域分配。尽管已经发现了一些控制蛋白质结构域模块化重排的机制，例如单个N端或C端结构域的添加或缺失，但这些重排背后的遗传学仍有很多未知之处。
