基质金属蛋白酶-2、基质金属蛋白酶-7、基质金属蛋白酶-9和金属蛋白酶组织抑制因子-1在慢性鼻-鼻窦炎和鼻息肉中的表达
The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis.
作者信息
Can Ilknur Haberal, Ceylan Kursat, Caydere Muzaffer, Samim Ethem Erdal, Ustun Huseyin, Karasoy Durdu Sertkaya
机构信息
ENT Clinic, Ministry of Health Ankara Education and Training Hospital, Ankara, Turkey.
出版信息
Otolaryngol Head Neck Surg. 2008 Aug;139(2):211-5. doi: 10.1016/j.otohns.2008.04.032.
OBJECTIVES
To investigate the expression and clinical significance of MMP-2, MMP-7, MMP-9, and TIMP-1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS).
STUDY DESIGN
Prospective study.
SUBJECTS AND METHODS
This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined.
RESULTS
Expression of MMP-2 was found significantly increased in NP, whereas MMP-7 expression was found significantly increased in CRS (P < 0.001). TIMP-1 was significantly high in control group compared to CRS and NP (P < 0.001 and P = 0.002, respectively).
CONCLUSIONS
Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.
目的
研究基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-7（MMP-7）、基质金属蛋白酶-9（MMP-9）和金属蛋白酶组织抑制因子-1（TIMP-1）在鼻息肉（NP）和慢性鼻-鼻窦炎（CRS）患者中的表达及临床意义。
研究设计
前瞻性研究。
对象与方法
本研究纳入54例患者。分为三组：鼻息肉组、慢性鼻-鼻窦炎组和对照组。在内镜鼻窦手术期间采集标本。对每个样本进行免疫组织化学检测。
结果
发现MMP-2在NP中的表达显著增加，而MMP-7在CRS中的表达显著增加（P < 0.001）。与CRS和NP相比，TIMP-1在对照组中显著升高（分别为P < 0.001和P = 0.002）。
结论
在这两种疾病中发现了基质金属蛋白酶激活的不同调节类型。如果黏膜中MMP-2表达强烈，则最终形成息肉；如果MMP-7表达强烈，则最终发展为CRS或维持CRS状态。
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