Alberghini V, Luberto F, Gobba F, Morelli C, Gori E, Tomesani N
Servizio di Medicina del Lavoro, USL 25 S. Giorgio di Piano.
Med Lav. 1991 Jan-Feb;82(1):18-24.
The mortality experience of 4,580 male farmers licensed to buy and use pesticides in Northern Italy was examined from 1974 to 1987. The historical cohort was determined from the registers of the agricultural inspectorate offices. The vital status at the end of the study period was ascertained by municipality records and only 4 subjects were lost to follow-up. Death certificates were obtained for 100% of the 565 identified deaths. External comparison on to the Italian male population was supplemented by regional comparison. Mortality deficits were observed for all causes, all neoplasms and most specific malignancies. A non-significant mortality excess due to brain cancer, compared both to national and regional populations, was found (11 cases, Standardized Mortality Ratio 169 and 139, respectively). The excess of brain cancer became statistically significant in the age group 65-75 years. Caution must be used in the interpretation of our findings. Nevertheless, it seems reasonable to hypothesize an association of the observed excess of brain cancer with the occupational and/or environmental exposure of the cohort.
对意大利北部4580名有购买和使用农药许可证的男性农民在1974年至1987年期间的死亡情况进行了调查。该历史性队列是根据农业监察办公室的登记记录确定的。研究期末的生命状态通过市政记录确定，仅有4名受试者失访。在确定的565例死亡病例中，100%获得了死亡证明。除了与意大利男性人口进行外部比较外，还进行了区域比较。观察到所有原因、所有肿瘤及大多数特定恶性肿瘤的死亡率均低于预期。与全国和区域人口相比，发现因脑癌导致的死亡率略有升高，但无统计学意义（11例，标准化死亡比分别为169和139）。在65 - 75岁年龄组中，脑癌死亡率的升高具有统计学意义。对我们的研究结果进行解读时必须谨慎。然而，推测所观察到的脑癌死亡率升高与该队列的职业和/或环境暴露有关似乎是合理的。
