Jess T, Zimmermann E, Kring S I I, Berentzen T, Holst C, Toubro S, Astrup A, Hansen T, Pedersen O, Sørensen T I A
Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark.
Int J Obes (Lond). 2008 Sep;32(9):1388-94. doi: 10.1038/ijo.2008.110. Epub 2008 Jul 29.
We investigated the impact of the fatness-related FTO rs9939609 A-allele on cross-sectional and longitudinal measures of body mass index (BMI), height and lean body mass (LBM) in a unique cohort representing a broad range of BMI.
A random sample of all men attending the Danish draft boards during 1943-1977 plus all men with a BMI>or=31.0 kg/m(2) (assuring representation of the right end of the distribution) was taken. Anthropometric measures were available at up to eight points in time from birth to adulthood in 1629 genotyped men. The odds ratio (OR) for being a carrier of FTO rs9939609 according to (1) one unit alteration in z-scores for BMI, height and LBM at given ages and (2) longitudinal changes in BMI and height z-scores were assessed by logistic regression.
Except at birth, the AA genotype was associated with increased BMI z-scores at all point during the monitored lifespan, starting at the age of 7 years. This effect remained stable until early adulthood, where further weight gain occurred. The AA genotype was also--mainly through the effect on fatness--associated with accelerated linear growth in childhood (age 7 years; OR, 1.36; 95% confidence interval (CI), 1.06-1.74) and increased LBM in adulthood (OR, 1.24; 95% CI, 1.14-1.35).
Fatness induced by FTO rs9939609 in early childhood is sustained until early adulthood, where further weight gain may occur. FTO rs9939609 may, however, also be associated with linear growth and LBM mainly through the effect on fat mass.
我们在一个代表广泛体重指数（BMI）范围的独特队列中，研究了与肥胖相关的FTO基因rs9939609 A等位基因对BMI、身高和瘦体重（LBM）的横断面及纵向测量指标的影响。
选取了1943年至1977年期间参加丹麦征兵体检的所有男性的随机样本，以及所有BMI≥31.0 kg/m²的男性（确保涵盖分布右端的代表性）。对1629名基因分型男性从出生到成年的多达八个时间点进行了人体测量。通过逻辑回归评估了根据（1）特定年龄时BMI、身高和LBM的z分数每变化一个单位以及（2）BMI和身高z分数的纵向变化，成为FTO rs9939609携带者的优势比（OR）。
除出生时外，AA基因型与监测寿命期间所有时间点（从7岁开始）BMI的z分数升高相关。这种影响在成年早期之前一直保持稳定，此后体重进一步增加。AA基因型还主要通过对肥胖的影响，与儿童期（7岁；OR，1.36；95%置信区间（CI），1.06 - 1.74）的线性生长加速以及成年期LBM增加（OR，1.24；95% CI，1.14 - 1.35）相关。
FTO rs9939609在幼儿期诱发的肥胖一直持续到成年早期，此时体重可能进一步增加。然而，FTO rs9939609也可能主要通过对脂肪量的影响与线性生长和LBM相关。
