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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Moriyama Y, Hiasa M, Matsumoto T, Omote H

Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Xenobiotica. 2008 Jul;38(7-8):1107-18. doi: 10.1080/00498250701883753.

Multidrug and toxic compound extrusion (MATE)-type transporters, which were first identified as a bacterial drug transporter family, are present in almost all prokaryotes and eukaryotes, and are thus one of the mostly conserved transporter families in nature. 2. Recently, a mammalian MATE transporter was shown to be a long hypothesized electroneutral H(+)/organic cation exporter that is responsible for the excretion of metabolic waste products and xenobiotics at renal brush border membranes and bile canaliculi. Plant MATE-type transporters are involved in the detoxification of metals and secondary metabolites such as phenols through their vesicular storage or extrusion at the plasma membrane. 3. Thus, MATE transporters are involved in one of the basic mechanisms that maintain homeostasis through the excretion of metabolic waste products and xenobiotics in nature.

多药及毒性化合物外排（MATE）型转运蛋白最初被鉴定为细菌药物转运蛋白家族，几乎存在于所有原核生物和真核生物中，因此是自然界中最保守的转运蛋白家族之一。2. 最近，一种哺乳动物MATE转运蛋白被证明是长期以来推测的电中性H(+)/有机阳离子外排转运体，负责在肾刷状缘膜和胆小管处排泄代谢废物和外源性物质。植物MATE型转运蛋白通过其在质膜上的囊泡储存或外排作用，参与金属和酚类等次生代谢物的解毒过程。3. 因此，MATE转运蛋白参与了自然界中通过排泄代谢废物和外源性物质来维持体内平衡的一种基本机制。

Moriyama Y, Hiasa M, Matsumoto T, Omote H

Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Xenobiotica. 2008 Jul;38(7-8):1107-18. doi: 10.1080/00498250701883753.

Multidrug and toxic compound extrusion (MATE)-type transporters, which were first identified as a bacterial drug transporter family, are present in almost all prokaryotes and eukaryotes, and are thus one of the mostly conserved transporter families in nature. 2. Recently, a mammalian MATE transporter was shown to be a long hypothesized electroneutral H(+)/organic cation exporter that is responsible for the excretion of metabolic waste products and xenobiotics at renal brush border membranes and bile canaliculi. Plant MATE-type transporters are involved in the detoxification of metals and secondary metabolites such as phenols through their vesicular storage or extrusion at the plasma membrane. 3. Thus, MATE transporters are involved in one of the basic mechanisms that maintain homeostasis through the excretion of metabolic waste products and xenobiotics in nature.

多药及毒性化合物外排（MATE）型转运蛋白最初被鉴定为细菌药物转运蛋白家族，几乎存在于所有原核生物和真核生物中，因此是自然界中最保守的转运蛋白家族之一。2. 最近，一种哺乳动物MATE转运蛋白被证明是长期以来推测的电中性H(+)/有机阳离子外排转运体，负责在肾刷状缘膜和胆小管处排泄代谢废物和外源性物质。植物MATE型转运蛋白通过其在质膜上的囊泡储存或外排作用，参与金属和酚类等次生代谢物的解毒过程。3. 因此，MATE转运蛋白参与了自然界中通过排泄代谢废物和外源性物质来维持体内平衡的一种基本机制。