Ichikawa Hiroo, Murakami Hidetomo, Katoh Hirotaka, Hieda Soutaro, Kawamura Mitsuru
Department of Neurology, Showa University School of Medicine, Tokyo.
Intern Med. 2008;47(15):1425-30. doi: 10.2169/internalmedicine.47.0868. Epub 2008 Aug 1.
We report four diabetic patients with a central pontine lesion on magnetic resonance imaging (MRI). All patients also had hypertension, diabetic neuropathy and nephropathy, and three had chronic hepatitis C. Their neurological symptoms were disproportionately mild compared with the MRI features, which were of high intensity on T2-weighted images, but were less prominent on T1- and diffusion-weighted images. A subclinical pontine lesion was found in two patients who had undergone MRI previously. We consider that diabetes mellitus is an important factor for developing a pontine lesion with or without symptoms, probably in association with hepato-renal problems and hypertension.
我们报告了4例在磁共振成像（MRI）上显示脑桥中央病变的糖尿病患者。所有患者均患有高血压、糖尿病性神经病变和肾病，3例还患有慢性丙型肝炎。与MRI表现相比，他们的神经症状相对较轻，MRI表现为T2加权图像上高信号，但在T1加权和扩散加权图像上不那么明显。在之前接受过MRI检查的2例患者中发现了亚临床脑桥病变。我们认为，糖尿病是发生有或无症状脑桥病变的一个重要因素，可能与肝肾问题和高血压有关。
