Section of Neurology, Department of Medical and Surgical Sciences of Communication and Behaviour, Ferrara University, Ferrara, Italy.
Neurol Sci. 2010 Jun;31(3):361-4. doi: 10.1007/s10072-009-0215-7. Epub 2010 Feb 11.
Central pontine myelinolysis is an acquired, non-inflammatory demyelinating lesion usually localized in the brainstem pons basis; it usually affects patients with a history of chronic alcoholism, malnutrition or dysionemia. The exact pathogenesis of myelinolysis is still unclear. A 69-year-old Caucasian male presented intensive headache and underwent cranial MRI that showed the typical feature of central pontine myelinolysis. Neurological valuation was negative. Other examinations included extensive blood tests, electroencephalogram and multimodal evoked potentials which all gave normal results. Alcohol abuse and malabsorption syndrome were excluded. The medical history revealed a continuative use of anti-depressive drugs and exposure to glue for years. Our patient may represent one of the rare cases of asymptomatic CPM. The actual reason why he presented this lesion is not clear, but we discuss the possible role in the etiopathogenesis of his chronic use of anti-depressive drugs and the exposure to glue and chemical agents.
脑桥中央髓鞘溶解症是一种获得性、非炎症性脱髓鞘病变，通常定位于脑桥基底；它通常影响有慢性酒精中毒、营养不良或电解质紊乱病史的患者。髓鞘溶解的确切发病机制仍不清楚。一位 69 岁的白人男性出现剧烈头痛，并进行了头颅 MRI，显示出脑桥中央髓鞘溶解症的典型特征。神经评估为阴性。其他检查包括广泛的血液检查、脑电图和多模态诱发电位，结果均正常。酒精滥用和吸收不良综合征被排除。病史显示他持续使用抗抑郁药，并多年接触胶水。我们的患者可能代表了无症状 CPM 的罕见病例之一。他出现这种病变的实际原因尚不清楚，但我们讨论了他慢性使用抗抑郁药和接触胶水及化学物质在发病机制中的可能作用。
