Fukuda T, Ohnishi Y, Terashima T, Iwafuchi M, Itoh S
Second Department of Pathology, Niigata Minami Hospital, Japan.
Acta Pathol Jpn. 1991 May;41(5):394-8. doi: 10.1111/j.1440-1827.1991.tb01664.x.
A case of ovarian carcinoid tumor of the trabecular type is presented. The small carcinoid tumor was found incidentally in a resected dermoid cyst. Histologically, the tumor was surrounded by a smooth muscle layer with focal stromal invasion. Non-carcinoid papillary mucosa and a few small glands, simulating the mucosa of the fallopian tube and remnant müllerian glands, respectively, were also present adjacent to the carcinoid tumor and enclosed by the same smooth muscle layer. The tumor cells revealed argyrophilia, and were positive for peptide tyrosine tyrosine (PYY) in the cytoplasm and for CEA in part of the luminal surface. This case was considered to be a rare ovarian carcinoid tumor arising from a dermoid cyst, without association of struma ovarii. PYY may be a potential marker for determining the histogenesis of ovarian carcinoid tumors.
本文报告一例小梁型卵巢类癌肿瘤。该小类癌肿瘤偶然发现于切除的皮样囊肿中。组织学上，肿瘤被平滑肌层包绕，有局灶性间质浸润。类癌肿瘤附近还存在非类癌乳头状黏膜及一些小腺体，分别类似于输卵管黏膜和残留的苗勒氏腺，且被同一平滑肌层包绕。肿瘤细胞显示嗜银性，细胞质中肽酪氨酸酪氨酸（PYY）呈阳性，部分腔面癌胚抗原（CEA）呈阳性。该病例被认为是起源于皮样囊肿的罕见卵巢类癌肿瘤，与卵巢甲状腺肿无关。PYY可能是确定卵巢类癌肿瘤组织发生的潜在标志物。
