Fiore J R, Angarano G, Fico C, Monno L, Zimatore G B, Di Stefano M, Fracasso C, Pastore G
Clinic of Infectious Diseases, University of Bari, Italy.
Acta Neurol (Napoli). 1991 Feb;13(1):31-6.
Seven paired HIV-1 isolates from peripheral blood mononuclear cells (PMCs) and cerebrospinal fluid (CSF) of infected subjects at various stages of the disease were studied for their capacity to replicate in continuous cell lines (Molt-3 and U-937 cells) and to induce cytopathic effects "in vitro". Obtained results indicate that paired HIV-1 isolates from PMCs and CSF of the same patient can differ in their replicative activity "in vitro", suggesting that, at least in some cases, CSF isolates may represent a distinct subtype of HIV-1.
对来自疾病不同阶段感染受试者外周血单核细胞（PMC）和脑脊液（CSF）的7对HIV-1分离株，研究了它们在连续细胞系（Molt-3和U-937细胞）中复制的能力以及“体外”诱导细胞病变效应的能力。获得的结果表明，来自同一患者PMC和CSF的成对HIV-1分离株在“体外”的复制活性可能不同，这表明，至少在某些情况下，CSF分离株可能代表HIV-1的一种独特亚型。
