Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Switzerland.
Neurobiol Aging. 2010 Jul;31(7):1132-44. doi: 10.1016/j.neurobiolaging.2008.07.019. Epub 2008 Sep 5.
Alzheimer's disease (AD) is likely to disrupt the synchronization of the bioelectrical processes in the distributed cortical networks underlying cognition. We analyze the surface topography of the multivariate phase synchronization (MPS) of multichannel EEG in 17 patients (Clinical Dementia Rating (CDR) Scale: 0.5-1; Functional Assessment Staging (FAST): 3-4) compared to 17 controls by applying a combination of global and regional MPS measures to the resting EEG. In early AD, whole-head mapping reveals a specific landscape of synchronization characterized by a decrease in MPS over the fronto-temporal region and an increase over the temporo-parieto-occipital region predominantly of the left hemisphere. These features manifest themselves through the EEG delta-beta bands and discriminate patients from controls with an accuracy of up to 94%. Moreover, the abnormal MPS in both anterior and posterior clusters correlates with the Mini Mental State Examination score, binding regional EEG synchronization to cognitive decline in AD patients. The MPS technique reveals that the EEG phenotype of early AD is relevant to the clinical picture and may ultimately become its sensitive and specific biomarker.
阿尔茨海默病（AD）很可能会破坏认知相关的分布式皮质网络中生物电过程的同步性。我们通过对静息 EEG 应用全局和区域多变量相位同步（MPS）测量的组合，对 17 名患者（临床痴呆评定量表（CDR）评分：0.5-1；功能评估分期（FAST）：3-4）与 17 名对照者的多通道 EEG 的 MPS 进行分析。在早期 AD 中，全头图揭示了一种以额颞区 MPS 降低和主要左半球颞顶枕区 MPS 增加为特征的特定同步景观。这些特征通过 EEG 德尔塔-贝塔波段表现出来，并且可以达到 94%的准确率将患者与对照者区分开来。此外，前后簇中的异常 MPS 与简易精神状态检查评分相关，将区域性 EEG 同步与 AD 患者的认知能力下降联系起来。MPS 技术表明，早期 AD 的 EEG 表型与临床表现相关，并且可能最终成为其敏感和特异性的生物标志物。
